产品货号：
Z22098
中文名称：
NME1抗体
英文名称：
Anti-NME1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NME1 Antibody |
| 指标别名 | AWD;GAAD;Granzyme A activated DNase;NB;NBS;NDK A;NDP kinase A;NDPK A;NDPKA;NME1;NM23;NM23-H1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC,FCM |
| 基因名称 | NME1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human NM23A(137-152aa EELVDYTSCAQNWIYE),different from the related mouse sequence by two amino acids and from rat sequence by one amino acid. |
| 实际分子量 | 17KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | NME1(NME/NM23 nucleoside diphosphate kinase 1) also called non-metastatic cells 1,protein(NM23A) expressed in,NM23,NM23-H1,NDPKA,GAAD or AWD,is an enzyme that in humans is encoded by the NME1 gene.The promoters of the mouse and human NME1 genes,like those of other NME genes,contain several binding sites for AP2,NF1,Sp1,LEF1,and response elements to glucocorticoid receptors.The NME1 gene is mapped on 17q21.33.Immunofluorescence microscopy demonstrated colocalization of NME1 in nuclei of B cells expressing EBNA3C.Expression of EBNA3C reversed the ability of NME1 to inhibit migration of BL and breast carcinoma cells.NM23H1 bound SET and was released from inhibition by GZMA cleavage of SET.After GZMA loading or cytotoxic T lymphocyte attack,SET and NM23H1 translocated to the nucleus and SET was degraded,allowing NM23H1 to nick chromosomal DNA.Using a Drosophila model system,Dammai et al.(2003) showed that the Drosophila NME1 homolog,awd,regulates trachea cell motility by modulating FGFR levels through a dynamin -mediated pathway. |
| Uniprot ID | P15531 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | NME/NM23 nucleoside diphosphate kinase 1 |
| 蛋白名全称 | Nucleoside diphosphate kinase A(NDK A) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 Immunocytochemistry 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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